これまでの業績

循環器研究室・動脈硬化研究グループ

1

Kawashiri MA, Tada H, Hashimoto M, Taniyama M, Nakano T, Nakajima K, Inoue T, Mori M, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Koizumi J, Ishihara H, Kobayashi J, Hirano T, Mabuchi H, Yamagishi M. Extreme Contrast of Postprandial Remnant-Like Particles Formed in Abetalipoproteinemia and Homozygous Familial Hypobetalipoproteinemia. JIMD Rep. 2015;22:85-94. DOI

2

Tada H, Melander O, Louie JZ, Catanese JJ, Rowland CM, Devlin JJ, Kathiresan S, Shiffman D. Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history. Eur Heart J. 2015 Sep 20. [Epub ahead of print] DOI

3

Tada H, Hosomichi K, Okada H, Kawashiri MA, Nohara A, Inazu A, Tomizawa S, Tajima A, Mabuchi H, Hayashi K. A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing. Clin Chim Acta. 2015 Dec 23;453:194-196. DOI

4

Tada H, Kawashiri MA, Konno T, Yamagishi M, Hayashi K. Common and Rare Variant Association Study for Plasma Lipids and Coronary Artery Disease. J Atheroscler Thromb. 2015 Sep 3. [Epub ahead of print] DOI

5

Tada H, Kawashiri MA, Yamagishi M, Hayashi K. Whole Exome Sequencing in Monogenic Dyslipidemias. J Atheroscler Thromb. 2015;22(9):881-5. DOI

6

Tada H, Kawashiri MA, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M. Autosomal recessive hypercholesterolemia: a mild phenotype of familial hypercholesterolemia: insight from the kinetic study using stable isotope and animal studies.

J Atheroscler Thromb. 2015;22(1):1-9. DOI

7

Tada H, Kawashiri MA, Yoshida T, Teramoto R, Nohara A, Konno T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K. Lipoprotein(a) in familial hypercholesterolemia with PCSK9 gain-of-function mutations. Circ J. 2015 Dec 2. [Epub ahead of print] DOI

8

Tada H, Kawashiri MA, Okada H, Teramoto R, Konno T, Yoshimuta T, Sakata K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M, Hayashi K. Assessment of coronary atherosclerosis in patients with familial hypercholesterolemia by coronary computed tomography angiography. Am J Cardiol. 2015 Mar 15;115(6):724-9. DOI

9

Tada H, Kawashiri MA, Takata M, Matsunami K, Imamura A, Matsuyama M, Sawada H, Nunoi H, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M. Infantile Cases of Sitosterolaemia with Novel Mutations in the ABCG5 Gene: Extreme Hypercholesterolaemia is Exacerbated by Breastfeeding. JIMD Rep. 2015;21:115-22. DOI

10

Tada H, Kawashiri MA, Yamagishi M, Hayashi K. Atrial fibrillation: an inherited cardiovascular disease: A commentary on genetics of atrial fibrillation: from families to genomes. J Hum Genet. 2015 Jun 11. [Epub ahead of print] DOI

11

Tada H, Kawashiri MA, Nakahashi T, Yagi K, Chujo D, Ohbatake A, Mori Y, Mori S, Kometani M, Fujii H, Nohara A, Inazu A, Mabuchi H, Yamagishi M, Hayashi K. Clinical characteristics of Japanese patients with severe hypertriglyceridemia.

J Clin Lipidol. 2015 Jul-Aug;9(4):519-24. DOI

12

Tada H, Kawashiri MA, Nohara A, Saito R, Tanaka Y, Nomura A, Konno T, Sakata K, Fujino N, Takamura T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K. Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene.

Atherosclerosis. 2015 Apr 7;240(2):324-329. DOI

13

Mori M, Yoshimuta T, Ohira M, Yagi M, Sakata K, Konno T, Kawashiri MA, Tomita S, Watanabe G, Iino K, Takemura H, Yamagishi M, Hayashi K. Impact of real-time three-dimensional transesophageal echocardiography on procedural success for mitral valve repair. J Echocardiogr. 2015 Sep;13(3):100-6. DOI

14

Hopkins PN, Defesche J, Fouchier SW, Bruckert E, Luc G, Cariou B, Sjouke B, Leren TP, Harada-Shiba M, Mabuchi H, Rabès JP, Carrié A, van Heyningen C, Carreau V, Farnier M, Teoh YP, Bourbon M, Kawashiri MA, Nohara A, Soran H, Marais AD, Tada H, Abifadel M, Boileau C, Chanu B, Katsuda S, Kishimoto I, Lambert G, Makino H, Miyamoto Y, Pichelin M, Yagi K, Yamagishi M, Zair Y, Mellis S, Yancopoulos GD, Stahl N, Mendoza J, Du Y, Hamon S, Krempf M, Swergold GD. Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and its Specific Treatment with Alirocumab, a PCSK9 Monoclonal Antibody. Circ Cardiovasc Genet. 2015 Dec;8(6):823-31. ランドマーク論文 DOI

15

Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabes JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias.

Circ Cardiovasc Genet. 2015 Apr;8(2):343-50. DOI

16

Mabuchi H, Nohara A, Noguchi T, Kobayashi J, Kawashiri MA, Inoue T, Mori M, Tada H, Nakanishi C, Yagi K, Yamagishi M, Ueda K, Takegoshi T, Miyamoto S, Inazu A, Koizumi J; Hokuriku FH Study Group. Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation. Atherosclerosis. 2014 Sep;236(1):54-61. DOI

17

Kawashiri MA, Ishibashi-Ueda H, Funada A, Yoshimuta T, Konno T, Hayashi K, Yamagishi M. Erdheim-Chester disease involving the brain and the heart.

J Am Coll Cardiol. 2014 Mar 25;63(11):1121 DOI

18

Kawashiri MA, Hayashi K, Konno T, Fujino N, Ino H, Yamagishi M. Current perspectives in genetic cardiovascular disorders: from basic to clinical aspects.

Heart Vessels. 2014 Mar;29(2):129-41. DOI

19

Kawashiri MA, Sakata K, Uchiyama K, Konno T, Namura M, Mizuno S, Tatami R, Kanaya H, Nitta Y, Michishita I, Hirase H, Ueda K, Aoyama T, Okeie K, Haraki T, Mori K, Araki T, Minamoto M, Oiwake H, Ino H, Hayashi K, Yamagishi M. Impact of lesion morphology and associated procedures for left main coronary stenting on angiographic outcome after intervention: sub-analysis of Heart Research Group of Kanazawa, HERZ, Study.

Cardiovasc Interv Ther. 2014 Apr;29(2):117-22. DOI

20

Kawashiri MA, Nomura A, Konno T, Hayashi K. Can next-generation sequencing replace sanger sequencing for screening genetic variants? Circ J. 2014;78(12):2845-7. DOI

21

Nohara A, Kobayashi J, Kawashiri MA, Tada H, Inazu A, Jiang M, Mabuchi H, Bujo H. Clinical significance of measuring soluble LR11, a circulating marker of atherosclerosis and HbA1c in familial hypercholesterolemia. Clin Biochem. 2014 Sep;47(13-14):1326-8. DOI

22

Katoh H, Nozue T, Kimura Y, Nakata S, Iwaki T, Kawano M, Kawashiri MA, Michishita I, Yamagishi M. Elevation of urinary liver-type fatty acid-binding protein as predicting factor for occurrence of contrast-induced acute kidney injury and its reduction by hemodiafiltration with blood suction from right atrium. Heart Vessels. 2014 Mar;29(2):191-7. DOI

23

Tada H, Won HH, Melander O, Yang J, Peloso GM, Kathiresan S. Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease. Circ Cardiovasc Genet. 2014 Oct;7(5):583-7. DOI

24

Tada H, Shiffman D, Smith JG, Sjogren M, Lubitz SA, Ellinor PT, Louie JZ, Catanese JJ, Engstrom G, Devlin JJ, Kathiresan S, Melander O. Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke. Stroke. 2014 Oct;45(10):2856-62. DOI

25

Tada H, Nohara A, Kawashiri MA, Inazu A, Mabuchi H, Yamagishi M. Marked transient hypercholesterolemia caused by low-dose mitotane as adjuvant chemotherapy for adrenocortical carcinoma. J Atheroscler Thromb. 2014;21(12):1326-9. DOI

26

Dullaart RP, Al-Daghri NM, Ashina M, Bouzas-Mosquera A, Brunetti ND, Buechler C, Chen HS, Corrales JJ, D’Archivio M, Dei Cas A, Pino GG, Gomez-Abril SA, Győri D, Haslacher H, Herder C, Kerstens MN, Koutsilieris M, Lombardi C, Lupattelli G, Mocsai A, Msaouel P, Orfao A, Ormazabal P, Pacher R, Perkmann T, Peteiro J, Plischke M, Reynaert NL, Ricci MA, Robles NR, Rocha M, Rutten EP, Sabico S, Santamaria F, Santoro F, Schmid A, Schmidt M, Schytz HW, Shyu KG, Tada H, Thorand B, Valerio G, Vesely DL, Wu TE, Yamagishi M, Yeh YT. Research update for articles published in EJCI in 2012. Eur J Clin Invest. 2014 Oct;44(10):1010-23. DOI

27

Kawashiri MA, Yamagishi M, Sakamoto T, Takayama T, Hiro T, Daida H, Hirayama A, Saito S, Yamaguchi T, Matsuzaki M; COSMOS Investigators. Impact of intensive lipid lowering on lipid profiles over time and tolerability in stable coronary artery disease: insights from a subanalysis of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS). Cardiovasc Ther. 2013 Dec;31(6):335-43. DOI

循環器研究室・分子心臓病研究グループ

1

Hayashi K, Konno T, Fujino F, Itoh H, Fujii Y, Imi-Hashida Y, Tada H, Tsuda T, Tanaka Y, Saito T, Ino H, Kawashiri M, Ohta K, Horie M, Yamagishi M. Impact of Updated Diagnostic Criteria for Long QT Syndrome on Clinical Detection of Diseased Patients: Results from Study of Patients Carrying Gene Mutations. JACC Clin Electrophysiol. 2016 (in press).

2

Konno T, Hayashi K, Fujino N, Yamagishi M. Hypokalemia and Disappearance of Giant Negative T Waves. Intern Med. 2016 (in press).

3

Nomura A, Tada H, Teramoto R, Konno T, Hodatsu A, Won HH, Kathiresan S, Ino H, Fujino N, 、Yamagishi M, Hayashi K. Whole Exome Sequencing Combined with Integrated Variant Annotation Prediction Identifies a Causative Myosin Essential Light Chain Variant in Hypertrophic Cardiomyopathy. J Cardiol. 2016 Feb;67(2):133-9. DOI

4

Hayashi K, Konno T, Tada H, Tani S, Liu L, Fujino N, Nohara A, Hodatsu A, Tsuda T, Tanaka Y, Kawashiri MA, Ino H, Makita N, Yamagishi M. Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.

Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1095-104. ランドマーク論文 DOI

5

Konno T, Nagata Y, Teramoto R, Fujino N, Nomura A, Tada H, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M, Hayashi K. Usefulness of Electrocardiographic Voltage to Determine Myocardial Fibrosis in Hypertrophic Cardiomyopathy.

Am J Cardiol. 2015 Nov 19 (in press). DOI

6

Konno T, Hayashi K, Fujino N, Oka R, Nomura A, Nagata Y, Hodatsu A, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M. Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy.

J Cardiovasc Electrophysiol. 2015 Oct;26(10):1081-7. DOI

7

Fujita T, Konno T, Yokawa J, Masuta E, Nagata Y, Fujino N, Funada A, Hodatsu A, Kawashiri MA, Yamagishi M, Hayashi K. Increased extent of myocardial fibrosis in genotyped hypertrophic cardiomyopathy with ventricular tachyarrhythmias. J Cardiol. 2015 Jul;66(1):63-8. DOI

8

Nagata Y, Konno T, Fujino N, Hodatsu A, Nomura A, Hayashi K, Nakamura H, Kawashiri MA, Yamagishi M. Right ventricular hypertrophy is associated with cardiovascular events in hypertrophic cardiomyopathy: evidence from study with magnetic resonance imaging.

Can J Cardiol. 2015 Jun;31(6):702-8. DOI

9

Nomura A, Konno T, Fujita T, Tanaka Y, Nagata Y, Tsuda T, Hodatsu A, Sakata K, Nakamura H, Kawashiri MA, Fujino N, Yamagishi M, Hayashi K. Fragmented QRS predicts heart failure progression in patients with hypertrophic cardiomyopathy. Circ J. 2015;79(1):136-43. DOI

10

Itoh H, Crotti L, Aiba T, Spazzolini C, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M. The genetics underlying acquired long QT syndrome: impact for genetic screening.

Eur Heart J. 2015 Dec 28 (in press). DOI

11

Yokoyama S, Al Mahmuda N, Munesue T, Hayashi K, Yagi K, Yamagishi M, Higashida H. Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population. Brain Sci. 2015 May 20;5(2):188-200. DOI

12

Fujino N, Konno T, Yamagishi M, Hayashi K. Left ventricular apical aneurysm and systolic dysfunction in hypertrophic cardiomyopathy. J Cardiol. 2014 Oct;64(4):253-5. DOI

13

Konno T, Hayashi K, Fujino N, Nagata Y, Hodatsu A, Masuta E, Sakata K, Nakamura H, Kawashiri MA, Yamagishi M. High sensitivity of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens in hypertrophic cardiomyopathy.

PLoS One. 2014 Jul 7;9(7):e101465. DOI

14

Hodatsu A, Konno T, Hayashi K, Funada A, Fujita T, Nagata Y, Fujino N, Kawashiri MA, Yamagishi M. Compound heterozygosity deteriorates phenotypes of hypertrophic cardiomyopathy with founder MYBPC3 mutation: evidence from patients and zebrafish models. Am J Physiol Heart Circ Physiol. 2014 Dec 1;307(11):H1594-604. ランドマーク論文 DOI

15

Fujino N, Konno T, Hayashi K, Hodatsu A, Fujita T, Tsuda T, Nagata Y, Kawashiri MA, Ino H, Yamagishi M. Impact of systolic dysfunction in genotyped hypertrophic cardiomyopathy.

Clin Cardiol. 2013 Mar;36(3):160-5. DOI

16

Fujita T, Fujino N, Anan R, Tei C, Kubo T, Doi Y, Kinugawa S, Tsutsui H, Kobayashi S, Yano M, Asakura M, Kitakaze M, Komuro I, Konno T, Hayashi K, Kawashiri MA, Ino H, Yamagishi M. Sarcomere gene mutations are associated with increased cardiovascular events in left ventricular hypertrophy: results from multicenter registration in Japan.

JACC Heart Fail. 2013 Dec;1(6):459-66. ランドマーク論文 DOI

17

Liu L, Hayashi K, Kaneda T, Ino H, Fujino N, Uchiyama K, Konno T, Tsuda T, Kawashiri MA, Ueda K, Higashikata T, Shuai W, Kupershmidt S, Higashida H, Yamagishi M. A novel mutation in the transmembrane nonpore region of the KCNH2 gene causes severe clinical manifestations of long QT syndrome. Heart Rhythm. 2013 Jan;10(1):61-7. DOI

18

Ma WJ, Hashii M, Munesue T, Hayashi K, Yagi K, Yamagishi M, Higashida H, Yokoyama S. Non-synonymous single-nucleotide variations of the human oxytocin receptor gene and autism spectrum disorders: a case-control study in a Japanese population and functional analysis. Mol Autism. 2013 Jul 1;4(1):22. DOI

循環器研究室・先進医工学研究グループ

1

Kawashiri MA, Nakanishi C, Tsubokawa T, Shimojima M, Yoshida S, Yoshimuta T, Konno T, Yamagishi M, Hayashi K. Impact of Enhanced Production of Endogenous Heme Oxygenase-1 by Pitavastatin on Survival and Functional Activities of Bone Marrow-derived Mesenchymal Stem Cells. J Cardiovasc Pharmacol. 2015 Jun;65(6):601-6. DOI

2

Yoshimuta T, Yokoyama H, Okajima T, Tanaka H, Toyoda K, Nagatsuka K, Higashi M, Hayashi K, Kawashiri MA, Yasuda S, Yamagishi M. Impact of Elevated D-Dimer on Diagnosis of Acute Aortic Dissection With Isolated Neurological Symptoms in Ischemic Stroke.

Circ J. 2015;79(8):1841-5. DOI

3

Tagawa S, Nakanishi C, Mori M, Yoshimuta T, Yoshida S, Shimojima M, Yokawa J, Kawashiri MA, Yamagishi M, Hayashi K. Determination of Early and Late Endothelial Progenitor Cells in Peripheral Circulation and Their Clinical Association with Coronary Artery Disease.

Int J Vasc Med. 2015;2015:674213.

4

Yoshida S, Tada H, Yamagishi M. Efficacy of Low-Density Lipoprotein Apheresis in Salvaging Critical Limb Ischemia Induced by Acute Thrombotic Occlusion on Peripheral Artery Disease. Ther Apher Dial. 2015 Sep 29. DOI

5

Tagawa S, Matsuda T, Aomizu T, Kuwana M, Ohtake H, et al. Surface-Bound Vascular Endothelial Growth Factor Promotes Prolonged Activation of Endothelial Cells: A New Technology for Capturing Endothelial Progenitor Cells by Intravascular Stents.

J Tissue Sci Eng. 2014; 5: 1000140.

6

Takabatake S, Hayashi K, Nakanishi C, Hao H, Sakata K, Kawashiri MA, Matsuda T, Yamagishi M. Vascular endothelial growth factor-bound stents: application of in situ capture technology of circulating endothelial progenitor cells in porcine coronary model.

J Interv Cardiol. 2014 Feb;27(1):63-72. ランドマーク論文 DOI

7

Yoshimuta T, Okajima T, Ishibashi-Ueda H, Mori M, Higashi M, Hayashi K, Kawashiri MA, Yamagishi M. Circumferential hyperechogenecity as an ultrasound sign of infected abdominal aortic aneurysm. Cirulation. 2013;128(4):415-6. DOI

循環器研究室・心血管疾患臨床研究グループ

1

Kawashiri MA, Sakata K, Gamou T, Kanaya H, Miwa K, Ueda K, Higashikata T, Mizuno S, Michishita I, Namura M, Nitta Y, Katsuda S, Okeie K, Hirase H, Tada H, Uchiyama K, Konno T, Hayashi K, Ino H, Nagase K, Terashima M, Yamagishi M. Impact of combined lipid lowering with blood pressure control on coronary plaque regression: rationale and design of MILLION study. Heart Vessels. 2015 Sep;30(5):580-6. DOI

2

Sakata K, Kawashiri MA, Hayashi K. Expansion of the clinical application of optical coherence tomography to percutaneous coronary intervention and assessment of the instability of coronary atherosclerosis. Circ J. 2015;79(3):513-4. DOI

3

Sakata K, Namura M, Takagi T, Tama N, Inoki I, Terai H, Horita Y, Ikeda M, Yamagishi M. Repeated occurrence of slow flow phenomenon during and late after sirolimus-eluting stent implantation. Heart Vessels. 2015 May;30(3):406-9. DOI

4

Gamou T, Sakata K, Matsubara T, Yasuda T, Miwa K, Inoue M, Kanaya H, Konno T, Hayashi K, Kawashiri M, Yamagishi M. Impact of thin-cap fibroatheroma on predicting deteriorated coronary flow during interventional procedures in acute as well as stable coronary syndromes: insights from optical coherence tomography analysis. Heart Vessels. 2015 Nov;30(6):719-27. DOI

5

Nakahashi T, Sakata K, Tsuda T, Tanaka Y, Ohira M, Mori M, Takata M, Kawashiri MA, Takemura H, Yamagishi M, Hayashi K. Abrupt progression of ventricular septal perforation after primary angioplasty for acute myocardial infarction.

Cardiovasc Diagn Ther. 2015 Dec;5(6):479-83. DOI

6

Yoshida T, Sakata K, Nitta Y, Taguchi T, Kaku B, Katsuda S, Shimojima M, Gamou T, Nakahashi T, Konno T, Kawashiri MA, Yamagishi M, Hayashi K. Short- and long-term benefits of drug-eluting stents compared to bare metal stents even in treatment for large coronary arteries.

Heart Vessels. 2015 Mar 11. [Epub ahead of print] DOI

7

Tanaka Y, Yoshimuta T, Yamagishi M, Sakata K. Video-assisted transmitral resection of primary cardiac lipoma originated from the left ventricular apex. Eur Heart J Cardiovasc Imaging. 2015 Apr;16(4):401 DOI

8

Tanaka Y, Sakata K, Waseda Y, Fujimura T, Yamada K, Oyama T, Kawashiri MA, Yamagishi M. Xiphodynia Mimicking Acute Coronary Syndrome. Intern Med. 2015;54(12):1563-6. DOI

9

Nakahashi T, Arita T, Yamaji K, Inoue K, Yokota T, Hoshii Y, Fukunaga M, Nomura A, Watanabe H, Miura S, Isotani A, Soga Y, Ando K, Iwabuchi M, Yokoi H, Nosaka H, Yamagishi M, Nobuyoshi M. Impact of clinical and echocardiographic characteristics on occurrence of cardiac events in cardiac amyloidosis as proven by endomyocardial biopsy.

Int J Cardiol. 2014 Oct 20;176(3):753-9. DOI

10

Tanaka Y, Sakata K, Kawashiri MA, Nakanishi C, Konno T, Yoshimuta T, Hayashi K, Tomita S, Watanabe G, Yamagishi M. Impact of fluoroscopically-visible fluttering flap on clinical diagnosis of acute aortic dissection. J Am Coll Cardiol. 2014 Apr 15;63(14):e31. DOI

内分泌糖尿病研究室

1

Karashima S, Yoneda T, Kometani M, Ohe M, Mori S, Sawamura T, Furukawa K, Seta T, Yamagishi M, Takeda Y. Comparison of eplerenone and spironolactone for the treatment of primary aldosteronism. Hypertens Res. 2015 Nov 26. [Epub ahead of print] DOI

2

Kometani M, Yoneda T, Demura M, Karashima S, Mori S, Oe M, Sawamura T, Okuda R, Yamagishi M, Takeda Y. Long-term effect of adrenal arterial embolization for unilateral primary aldosteronism on cardiorenovascular protection, blood pressure, and endocrinological profile. Intern Med. 2015 (in press).

3

Oka R, Aizawa T, Miyamoto S, Yoneda T, Yamagishi M. One-hour plasma glucose as a predictor of the development of Type 2 diabetes in Japanese adults. Diabet Med. 2015 Oct 19. [Epub ahead of print] DOI

4

Demura M, Demura Y, Takeda Y, Saijoh K. Dynamic regulation of the angiotensinogen gene by DNA methylation, which is influenced by various stimuli experienced in daily life. Hypertens Res. 2015 Aug;38(8):519-27. DOI

5

Biyani M, Kawai K, Kitamura K, Chikae M, Biyani M, Ushijima H, Tamiya E, Yoneda T, Takamura Y. PEP-on-DEP: A competitive peptide-based disposable electrochemical aptasensor for renin diagnostics. Biosens Bioelectron. 2015 Dec 24. [Epub ahead of print] DOI

6

Ito N, Yagi K, Kawano M, Mori Y, Okazaki S, Chujo D, Takeda Y, Kobayashi J, Yamagishi M. Analysis of pancreatic endocrine function in patients with IgG4-related diseases, in whom autoimmune pancreatitis was ruled out by diagnostic imaging. Endocr J. 2014;61(8):765-72. DOI

7

Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y. Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene. Hypertension. 2014 ;63(2):281-8. DOI

8

Okazaki-Sakai S, Yoshimoto S, Yagi K, Wakasugi T, Takeda Y, Yamagishi M. Insulin autoimmune syndrome caused by an adhesive skin patch containing loxoprofen-sodium. Intern Med. 2013;52(21):2447-51. DOI

9

Yamaaki N, Yagi K, Kobayashi J, Nohara A, Ito N, Asano A, Nakano K, Liu J, Okamoto T, Mori Y, Ohbatake A, Okazaki S, Takeda Y, Yamagishi M. Impact of serum retinol-binding protein 4 levels on regulation of remnant-like particles triglyceride in type 2 diabetes mellitus. J Diabetes Res. 2013;2013:143515. DOI

リウマチ・膠原病研究室

1

Kawano M, Suzuki Y, Yamada K, Mizushima I, Matsumura M, Nakajima K, Yamagishi M, Yamaguchi Y. Primary Sjögren’s syndrome with chronic tubulointerstitial nephritis and lymphadenopathy mimicking IgG4-related disease.

Mod Rheumatol. 2015 Jul;25(4):637-41. DOI

2

Kawano M, Saeki T. IgG4-related kidney disease–an update. Curr Opin Nephrol Hypertens. 2015 Mar;24(2):193-201. DOI

3

Kawano M, Mizushima I, Yamada K, Taniguchi Y, Saeki T. IgG4-related kidney disease. Diagnosis and treatment Nihon Rinsho Meneki Gakkai Kaishi. 2015;38(1):8-16. DOI

4

Yamada K, Zoshima T, Ito K, Mizushima I, Hara S, Horita S, Nuka H, Hamano R, Fujii H, Yamagishi M, Kawano M. A case developing minimal change disease during the course of IgG4-related disease. Mod Rheumatol. 2015 Mar 24:1-4 (in press). DOI

5

Mori K, Yamada K, Konno T, Inoue D, Uno Y, Watanabe M, Okuda M, Oe K, Kawano M, Yamagishi M. Pericardial Involvement in IgG4-related Disease.

Intern Med. 2015;54(10):1231-5. DOI

6

Zoshima T, Yamada K, Hara S, Mizushima I, Yamagishi M, Harada K, Sato Y, Kawano M. Multicentric Castleman Disease With Tubulointerstitial Nephritis Mimicking IgG4-related Disease: Two Case Reports. Am J Surg Pathol. 2015 Nov 20 (in press). DOI

7

Khosroshahi A, Wallace ZS, Crowe JL, Akamizu T, Azumi A, Carruthers M, Chari S, Della-Torre E, Frulloni L, Goto H, Hart P, Kamisawa T, Kawa S, Kawano M, Kim MH, Kodama Y, Kubota K, Lerch MM, Lohr M, Masaki Y, Matsui S, Mimori T, Nakamura S, Nakazawa T, Ohara H, Okazaki K, Ryu JH, Saeki T, Schleinitz N, Shimatsu A, Shimosegawa T, Takahira M, Takahashi H, Tanaka A, Topazian M, Umehara H, Webster G, Witzig T, Yamamoto M, Zhang W, Chiba T, Stone JH. International consensus guidance statement on the management and treatment of IgG4-related disease. Arthritis Rheumatol. 2015 Mar 25. DOI

8

Mizushima I, Inoue D, Yamamoto M, Yamada K, Saeki T, Ubara Y, Matsui S, Masaki Y, Wada T, Kasashima S, Harada K, Takahashi H, Notohara K, Nakanuma Y, Umehara H, Yamagishi M, Kawano M. Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study. Arthritis Res Ther. 2014 Jul 23;16(4):R156. DOI

9

Ito K, Furukawa J, Yamada K, Tran NL, Shinohara Y, Izui S. Lack of galactosylation enhances the pathogenic activity of IgG1 but Not IgG2a anti-erythrocyte autoantibodies. J Immunol. 2014 Jan 15;192(2):581-8. DOI

10

Umehara H, Nakajima A, Nakamura T, Kawanami T, Tanaka M, Dong L, Kawano M. IgG4-related disease and its pathogenesis-cross-talk between innate and acquired immunity. Int Immunol. 2014 Nov;26(11):585-95. DOI

11

Saeki T, Kawano M. IgG4-related kidney disease. Kidney Int. 2014 Feb;85(2):251-7. DOI

12

Yamada K, Ito K, Furukawa J, Nakata J, Alvarez M, Verbeek JS, Shinohara Y, Izui S. Galactosylation of IgG1 modulates FcγRIIB-mediated inhibition of murine autoimmune hemolytic anemia. J Autoimmun. 2013 Dec;47:104-10. DOI

13

Yamada K, Hamaguchi Y, Saeki T, Yagi K, Ito N, Kakuchi Y, Yamagishi M, Takehara K, Nakanuma Y, Kawano M. Investigations of IgG4-related disease involving the skin. Mod Rheumatol. 2013 Sep;23(5):986-93. DOI

14

Ito K, Yamada K, Mizushima I, Aizu M, Fujii H, Mizutomi K, Matsumura M, Hayashi K, Yamagishi M, Umehara H, Yamaguchi Y, Nagata M, Kawano M. Henoch-Schönlein purpura nephritis in a patient with IgG4-related disease: a possible association.

Clin Nephrol. 2013 Mar;79(3):246-52. DOI

15

Ito K, Baudino L, Kihara M, Leroy V, Vyse TJ, Evans LH, Izui S. Three Sgp loci act independently as well as synergistically to elevate the expression of specific endogenous retroviruses implicated in murine lupus. J Autoimmun. 2013 Jun;43:10-7. DOI

16

Zoshima T, Matsumura M, Suzuki Y, Kakuchi Y, Mizushima I, Fujii H, Yamada K, Yamagishi M, Kawano M. A case of refractory cutaneous polyarteritis nodosa in a patient with hepatitis B carrier status successfully treated with tumor necrosis factor alpha blockade. Mod Rheumatol. 2013 Sep;23(5):1029-33. DOI

消化管免疫研究室

1

Sawada T, Yamamoto E, Yamano HO, Nojima M, Harada T, Maruyama R, Ashida M, Aoki H, Matsushita HO, Yoshikawa K, Harada E, Tanaka Y, Wakita S, Niinuma T, Kai M, Eizuka M, Sugai T, Suzuki H. Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations. Oncotarget. 7: 35106-18, 2016.

2

Yoshimitsu M, Sawada T, Kobayashi T, Yamagishi M. Dabigatran-induced exfoliative esophagitis. Intern Med. 55: 1815, 2016.

2

Tsuji S, Nohara A, Hayashi Y, Yoshida I, Oka R, Moriuchi T, Hagishita T, Miyamoto S, Suzuki A, Okada T, Yamagishi M. Impact of gastrectomy on high-density lipoprotein cholesterol elevation in nonobese patients during a 10-year follow-up. J Atheroscler Thromb. 22: 235-246, 2015. DOI

その他、他施設

1

Sawada T, Maeno K, Joh T. Esophageal ulcer in lung cancer patient.

Gastroenterology. 149: e6-7, 2015. DOI

2

Sakata K, Koo BK, Waseda K, Nakatani D, Yock PG, Whitbourn R, Worthley SG, Ormiston J, Webster M, Wilkins GT, Honda Y, Meredith IT, Fitzgerald PJ. A Y-shaped bifurcation-dedicated stent for the treatment of de novo coronary bifurcation lesions: an IVUS analysis from the BRANCH trial.

EuroIntervention. 2015 Mar 22;10(11):e1-8. DOI

3

Funada A, Kanzaki H, Noguchi T, Morita Y, Sugano Y, Ohara T, Hasegawa T, Hashimura H, Ishibashi-Ueda H, Kitakaze M, Yasuda S, Ogawa H, Anzai T. Prognostic significance of late gadolinium enhancement quantification in cardiac magnetic resonance imaging of hypertrophic cardiomyopathy with systolic dysfunction. Heart Vessels. 2015 Mar 28. [Epub ahead of print] DOI

4

Funada A, Kanzaki H, Nagano N, Sugano Y, Ohara T, Hasegawa T, Ishibashi-Ueda H, Kitakaze M, Anzai T. Late aneurysm formation of Valsalva sinus after aortic valve replacement due to Takayasu’s arteritis. Heart Vessels. 2015 Jul;30(4):558-62. DOI

5

Hara S, Kobayashi N, Sakamoto K, Ueno T, Manabe S, Takashima Y, Hamada J, Pastan I, Fukamizu A, Matsusaka T, Nagata M. Podocyte injury-driven lipid peroxidation accelerates the infiltration of glomerular foam cells in focal segmental glomerulosclerosis. Am J Pathol. 2015 Aug;185(8):2118-31. DOI

6

Hara S, Umeyama K, Yokoo T, Nagashima H, Nagata M. Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha, an inheritant diabetic gene in humans. PLoS One. 2014 Mar 19;9(3):e92219. DOI

7

Sawada T, Yamamoto E, Suzuki H, Nojima M, Maruyama R, Shioi Y, Akasaka R, Kamimae S, Harada T, Ashida M, Kai M, Adachi Y, Yamamoto H, Imai K, Toyota M, Itoh F, Sugai T. Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization. Genes Chromosomes Cancer. 52: 140-9, 2013. DOI

8

Sawada T, Adachi Y, Noda M, Akino K, Kikuchi T, Mita H, Ishii Y, Endo T. Hepatic portal venous gas in pancreatic solitary metastasis from an esophageal squamous cell carcinoma. Hepatobiliary Pancreat Dis Int. 12: 103-5, 2013. DOI

9

Sawada T, Yoshida M, Adachi Y, Endo T. Small intestinal lipoma causing obscure gastrointestinal bleeding. Intern Med. 52: 633-4, 2013. DOI

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