消化管免疫研究室

消化管免疫研究室

消化管免疫研究室

主な研究内容

  1. 大腸鋸歯状病変のゲノム、エピゲノム解析と、内視鏡像を含む臨床病理学的因子との関連の検討
  2. 循環腫瘍DNA、循環腫瘍細胞の遺伝子解析による消化管癌の診断および治療効果予測バイオマーカーの探索
  3. 大腸癌の間質における腫瘍関連マクロファージの遺伝子発現の解析と治療への応用

詳細な研究実績(論文)はこちらへ。

研究室の概要

消化管免疫研究室

臨床面においては、消化管、肝臓、胆嚢、膵臓の幅広い疾患を対象としており、多様な症例を経験できます。上部消化管内視鏡、大腸内視鏡、小腸内視鏡、超音波検査等を用いた各種診断学、また内視鏡及び超音波を用いた各種治療学などの臨床的技能の習得が可能です。また、石川県立中央病院、福井県立病院などの関連施設における研修も可能で、拡大内視鏡を用いた診断学や、内視鏡的粘膜下層剥離術など高度な内視鏡治療手技の習得が可能です。
研究面においては、従来から多様な疾患の遺伝子解析研究を行い、数々の業績を挙げてきました。現在、大腸の腫瘍性病変の臨床検体を用いた遺伝子解析を札幌医科大学分子生物学講座、名古屋市立大学消化器・代謝内科学講座などの国内の研究施設と共同で行っています。今後、関連施設や共同研究施設から検体の提供を受け、研究対象を拡大する予定です。

これまでの業績

1

Sawada T, Yamamoto E, Yamano HO, Nojima M, Harada T, Maruyama R, Ashida M, Aoki H, Matsushita HO, Yoshikawa K, Harada E, Tanaka Y, Wakita S, Niinuma T, Kai M, Eizuka M, Sugai T, Suzuki H. Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations. Oncotarget 7: 35106-18, 2016.

2

Tsuji S, Nohara A, Hayashi Y, Yoshida I, Oka R, Moriuchi T, Hagishita T, Miyamoto S, Suzuki A, Okada T, Yamagishi M. Impact of gastrectomy on high-density lipoprotein cholesterol elevation in nonobese patients during a 10-year follow-up. J Atheroscler Thromb 22: 235-246, 2015.

3

Yoshimitsu M, Sawada T, Kobayashi T, Yamagishi M. Dabigatran-induced exfoliative esophagitis. Intern Med, 55: 1815, 2016.

4

柳瀬祐孝, 早稲田洋平, 齊藤奈津子, 大石岳, 岡田和弘, 小林武嗣, 金子周一. 抗凝固療法中に巨大な胃粘膜下血腫を呈した多発性骨髄腫にともなうAL型アミロイドーシスの1例. 日本消化器病学会雑誌 112: 1023-1029, 2015.

5

後藤善則, 脇田重徳, 吉光雅志, 稲垣聡子, 小林武嗣, 金子周一. SOX療法にて抗利尿ホルモン分泌不適合症候群を発症した胃癌の1例. Jpn J Cancer Chemother 42:2467-70, 2015.

6

Miwa K, Doyama H, Ito R, Nakanishi H, Hirano K, Inagaki S, Tominaga K, Yoshida N, Takemura K, Yamada S, Kaneko Y, Katayanagi K, Kurumaya H, Okada T, Yamagishi M. Can magnifying endoscopy with narrow band imaging be useful for low grade adenomas in preoperative biopsy specimens? Gastric Cancer 15: 170-178, 2012.

7

Hayashi Y, Narumi K, Tsuji S, Tsubokawa T, Nakaya MA, Wakayama T, Zuka M, Ohshima T, Yamagishi M, Okada T. Impact of adrenomedullin on dextran sulfate sodium-induced inflammatory colitis in mice: insights from in vitro and in vivo experimental studies. Int J Colorectal Dis 26: 1453-1462, 2011.

8

Kaneko Y, Miyajima H, Piperno A, Tomosugi N, Hayashi H, Morotomi N, Tsuchida K, Ikeda T, Ishikawa A, Ota Y, Wakusawa S, Yoshioka K, Kono S, Pelucchi S, Hattori A, Tatsumi Y, Okada T, Yamagishi M. Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders. J Gastroenterol 45: 1163-1171, 2010.

9

Okada T, Shiono Y, Kaneko Y, Miwa K, Hasatani K, Hayashi Y, Mibayashi H, Aoyagi H, Tsuji S, Yoshimitsu M, Hayashi H, Yamagishi M. High prevalence of fulminant hepatic failure among patients with mutant alleles for truncation of ATP7B in Wilson’s disease. Scand J Gastroenterol 45: 1232-1237, 2010.

関連病院の業績

1

Tsuji S, Doyama H, Tsuji K, Tsuyama S, Tominaga K, Yoshida N, Takemura K, Yamada S, Niwa H, Katayanagi K, Kurumaya H, Okada T. Preoperative endoscopic diagnosis of superficial
non-ampullary duodenal epithelial tumors, including magnifying endoscopy. World J Gastroenterol 21: 11832-11841, 2015.

2

Yamada S, Doyama H, Ota R, Takeda Y, Tsuji K, Tsuji S, Yoshida N. Impact of the clip and snare method using the prelooping technique for colorectal endoscopic submucosal dissection. Endoscopy 2016 Mar;48(3):281-5.

3

Yoshida N, Doyama H, Nakanishi H, Tsuji K, Tominaga K, Matsunaga K, Tsuji S, Takemura K, Yamada S, Tsuyama S, Katayanagi K, Kurumaya H. White globe appearance is a novel specific endoscopic marker for gastric cancer: A prospective study. Dig Endosc. 2016 Jan;28(1):59-66.

4

Doyama H, Yoshida N, Tsuyama S, Ota R, Takeda Y, Nakanishi H, Tsuji K, Tominaga K, Tsuji S, Takemura K, Yamada S, Katayanagi K, Kuruyama H, Iwashita A, Yao K. The “white globe appearance” (WGA): a novel marker for a correct diagnosis of early gastric cancer by magnifying endoscopy with narrow-band imaging (M-NBI). Endosc Int Open 3: E120-124, 2015.

5

Waseda Y, Doyama H, Inaki N, Nakanishi H, Yoshida N, Tsuji S, Takemura K, Yamada S, Okada T. Does laparoscopic and endoscopic cooperative surgery for gastric submucosal tumors preserve residual gastric motility? Results of retrospective single-center study. PLoS One 9: e101337, 2014.

6

Doyama H, Tominaga K, Yoshida N, Takemura K, Yamada S. Endoscopic tissue shielding with polyglycolic acid sheets, fibrin glue and clips to prevent delayed perforateon after duodenal endoscopic resection. Dig Endosc 26 (Suppl 20): 41-45, 2014.

7

Tsuji K, Doyama H, Takeda Y, Takemura K, Yoshida N, Kito Y, Asahina Y, Ito R, Nakanishi H, Hayashi T, Inagaki S, Tominaga K, Waseda Y, Tsuji S, Yamada S, Hino S, Okada T. Use of transoral endoscopy for pharynxeal examination: cross-sectional analysis.
Dig Endosc 26:344-349, 2014.

8

Nakanishi H, Doyama H, Takemura K, Yoshida N, Tsuji K, Takeda Y, Asahina Y, Kito Y, ItoR, Hayashi T, Hirano K, Goto Y, Tominaga K, Inagaki S, Waseda Y, Tsuji S, Miwa K, Kaneko Y, Yamada S, Kurumaya H, Sakumoto M, Okada T. Detection of pharyngeal cancer in the overall population undergoing upper GI endoscopy by using narrow-band imaging: a single-center experience, 2009-2012. Gastrointest Endosc 79:558-564, 2014.

9

Yamada S, Doyama H, Yao K, Uedo N, Ezoe Y, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, Ishikawa H, Takeuchi Y, Saito Y, Muto M. An efficient diagnostic strategy for small, depressed early gastric cancer with magnifying narrow-band imaging: a post-hoc analysis of a prospective randomized controlled trial. Gastrointest Endosc 79:55-63, 2014.

10

Takemura K, Doyama H, Nakanishi H, Takeda Y, Kito Y, Ito R, Hayashi T, Tsuji K, Tominaga K, Yoshida N, Waseda Y, Tsuji S, Yamada S, Niwa H, Katayanagi K, Kurumaya H, Okada T. Can flat-type brownish microlesions in the orohypopharynx be followed up without biopsy or endoscopic resection? Dig Endosc 26:178-182, 2014.

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